Publications

2022

Larsson DSD, Kanchugal P S & Selmer M (2022), “Structural consequences of deproteinating the 50S ribosome”, Biomolecules 12, 1605 doi: 10.3390/biom12111605
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2021

Brewster JL,  Pachl P, McKellar JLO, Selmer M, Squire CJ & Patrick WM (2021), “Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis”J Biol Chem 296:100797 doi: 10.1016/j.jbc.2021.100797
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Guo X,  Söderholm A, Kanchugal P S, Isaksen GV, Warsi O, Eckhard U, Trigüis S, Gogoll A, Jerlström-Hultqvist J, Åqvist J, Andersson DI & Selmer M (2021), “Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family”, eLife 10:e61818. doi: 10.7554/eLife.61818.
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2020

Gustafsson R, Eckhard U, Ye W, Enbody ED, Pettersson M, Jemth P, Andersson L, Selmer M (2020) "Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding", Biomolecules 10(12):E1631. doi: 10.3390/biom10121631.
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Söderholm A, Newton M S, Patrick W M & Selmer M (2020), “Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa - decarboxylation is not essential for indole formation”J Biol Chem 295(47):15948-15956. doi: 10.1074/jbc.RA120.014936.
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Kanchugal P S & Selmer M (2020), “Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalisAntimicrob Agents Chemother May 21;64(6):e00371-20. doi: May 21;64(6):e00371-20.
pubmed paper  bioRxiv preprint 

Durall C, Kanchugal P S, Selmer M & Lindblad P (2020), “Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002”Sci Rep Feb 27; 10:3607. doi: 10.1038/s41598-020-60249-2.
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2019

Stsiapanava A, Selmer M (2019), “Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance”Sci Rep Oct 10; 9(1):14607. doi: 10.1038/s41598-019-51174-0.
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2018

Stern AL*, Van der Verren SE*, Kanchugal P S*, Näsvall J, Gutierrez de Teran H, Selmer M (2018), “Structural mechanism of AadA, a dual specificity aminoglycoside adenylyl transferase from Salmonella entericaJ Biol Chem doi: 10.1074/jbc.RA118.003989.
*These authors contributed equally
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Jerlström Hultqvist J, Warsi O, Söderholm A, Knopp M, Eckhard U, Vorontsov E, Selmer M, Andersson DI. (2018), “A bacteriophage enzyme induces bacterial metabolic perturbation that confers a novel promiscuous function”Nat Ecol Evol Aug;2(8):1321-1330. doi: 10.1038/s41559-018-0568-5.
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2017

Newton MS, Guo X, Söderholm A, Näsvall J, Lundström P, Andersson DI, Selmer M, Patrick WM. (2017) "Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes." Proc Natl Acad Sci U S A 114(18):4727-4732. doi: 10.1073/pnas.1618552114. 
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2016

Ieong KW, Uzun Ü, Selmer M, Ehrenberg M. (2016) "Two proofreading steps amplify the accuracy of genetic code translation". Proc Natl Acad Sci U S A 113(48):13744-13749. doi: 10.1073/pnas.1610917113.
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2015

Chen Y, Näsvall J, Wu S, Andersson DI, Selmer M. (2015) Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase. Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2267-77. doi: 10.1107/S1399004715016429.
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Söderholm A, Guo X, Newton MS, Evans GB, Näsvall J, Patrick WM, Selmer M. (2015) Two-step Ligand Binding in a (βα)8 Barrel Enzyme: Substrate-bound structures shed new light on the catalytic cycle of HisA. J Biol Chem. 290(41):24657-68. doi: 10.1074/jbc.M115.678086.
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2014

Sun S., Selmer M., Andersson D.I. (2014), “Resistance to β-lactam antibiotics conferred by point mutations in penicillin-binding proteins PBP3, PBP4 and PBP6 in Salmonella enterica.”, PLoS One 9(5):e97202. doi: 10.1371/journal.pone.0097202. eCollection 2014.
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2013

Punekar A.S. & Selmer M. (2013), “Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli” Acta Cryst. F 69, 1001-1003 
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Punekar A.S., Liljeruhm J., Shepherd T.R., Forster A.C. & Selmer M. (2013), “Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ”, Nucleic Acids Research. 41(20):9537-48. doi: 10.1093/nar/gkt719.
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Hultqvist G, Haq SR, Punekar AS, Chi CN, Engström A, Bach A, Strømgaard K, Selmer M, Gianni S, Jemth P. (2013), “Energetic Pathway Sampling in a Protein Interaction Domain.”, Structure doi:pii: S0969-2126(13)00192-5. 10.1016/j.str.2013.05.010. Epub ahead of print
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2012

Hultqvist G., Punekar A.S., Morrone A., Chi C.N., Engström Å., Selmer M., Gianni S. & Jemth P. (2012), “Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain”, PLOS One. 7(11): 50055. doi:10.1371/journal.pone.0050055
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Punekar A.S., Shepherd T.R., Liljeruhm J., Forster A.C. & Selmer M. (2012), “Crystal structure of RlmM, the 2′O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA”, Nucleic Acids Research. 40(20):10507-20. doi: 10.1093/nar/gks727. 
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Koripella R.K., Chen Y., Peisker K., Koh C.S., Selmer M. & Sanyal S. (2012), “Mechanism of elongation factor-G mediated fusidic acid resistance and fitness compensation in Staphylococcus aureus, J. Biol. Chem. 287(36):30257-67.
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Selmer M., Gao Y.G., Weixlbaumer A. & Ramakrishnan V. (2012), “Ribosome engineering to promote new crystal forms”, Acta Cryst. D 68:578-583
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Guo, X., Peisker, K., Bäckbro, K., Chen, Y., Kiran Koripella, R., Mandava, C.S., Sanyal, S. & Selmer, M. (2012), “Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling”, Open Biol., 2: 120016
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2010

Chen, Y., Kiran Koripella, R., Sanyal, S. and Selmer, M. (2010), “Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid”, FEBS J., 277(18):3789-803
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Haq S.R., Jürgens M.C., Chi C.N., Koh C.S., Elfström L., Selmer M., Gianni S., Jemth P. (2010), "The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain", J. Biol. Chem., 285(23):18051-9
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2009

Gao Y.G., Selmer M., Dunham C.M., Weixlbaumer A., Kelley A.C. and Ramakrishnan V. (2009), "The structure of the ribosome with elongation factor G trapped in the posttranslocational state", Science, 326(5953):694-9
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2008

Selmer, M. and Liljas A. (2008), "Exit biology: battle for the nascent chain"Structure 16:498-500 (preview)
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2007

Dunham, C.M.*, Selmer, M.*, Phelps, S., Kelley, A.C., Suzuki, T., Joseph, S. and Ramakrishnan, V. (2007), “Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S Ribosomal Subunit”, RNA, 13(6):817-23, Epub April 6 2007
*These authors contributed equally
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Weixlbaumer A., Petry, S.#, Dunham, C.M.#, Selmer, M.#, Kelley, A.C. and Ramakrishnan V. (2007), “Crystal structure of the ribosome recycling factor bound to the ribosome”, Nature Struct. Mol. Biol., 14(8): 733-737, Epub July 29 2007; doi:10.1038/nsmb1282
#These authors contributed equally
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2006

Selmer, M.*, Dunham, C.M.*, Murphy, F.V. IV, Weixlbaumer, A., Petry, S., Kelley, A.C., Weir, J.R. and Ramakrishnan, V. (2006), “Structure of the 70S ribosome complexed with mRNA and tRNA”, Science, Published online September 7 2006; 10.1126/science.1131127
*These authors contributed equally
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2005

Petry, S., Brodersen, D.E., Murphy, F.V. IV, Dunham, C.M., Selmer, M., Tarry, M.J., Kelley, A.C. and Ramakrishnan, V. (2005), “Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon”, Cell 123:1255–1266
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2004

Laurberg, M., Kristensen, O., Selmer, M., Su, X.-D. and Liljas, A. 2004. How do translation factors catalyze protein synthesis. In R. Holland Cheng & Lena Hammar, Eds "Conformational proteomics of Macromolecular Architecture" World Publishing Co. Pte. Ltd. Singapore. Chapter 14, pp307-329.

2003

Nikulin, A., Eliseikina, E., Tishchenko, S., Nevskaya, N., Davydova, N., Platonova, O., Piendl, W., Selmer, M., Liljas, A., Drygin, D., Zimmermann, R., Garber, M. and Nikonov, S. (2003), “Structure of the L1 protuberance in the ribosome”, Nature Struct. Biol. 10(2):104-108
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2002

Selmer, M., Wilting, R., Holmlund, D. and Su, X-D. (2002), “Preparation of a crystallizable mRNA binding domain of Moorella thermoacetica elongation factor SelB”, Acta Cryst D 58:1871-1873
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Selmer, M. and Su, X-D. (2002), “Crystal structure of an mRNA binding fragment of Moorella thermoacetica elongation factor SelB”, EMBO J. 41:4145-4153
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Hirokawa, G., Kiel, M.C., Muto, A., Selmer, M., Liljas, A., Igarashi, K. and Kaji, A. (2002), “Release of tRNA and mRNA from the post-termination complex by Elongation Factor G and Ribosome Recycling Factor, a functional tRNA mimic", EMBO J. 21:2272-2281
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Selmer, M. (2002) “Protein-RNA interplay in translation. Structural studies of RRF, SelB and L1.” doctoral thesis, Lund University
summary

Kristensen, O., Laurberg, M., Liljas, A. and Selmer, M. (2002), ”Is tRNA mimicry or tRNA binding mandatory for translation factors?”, Curr. Prot. Pept. Sci. 3:133-141 (review)
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2001

Fedorov, R., Meshcheryakov,V., Gongadze, G., Fomenkova, N., Nevskaya, N., Selmer, M., Laurberg, M., Kristensen, O., Al Karadaghi, S., Liljas, A., Garber, M. and Nikonov, S. (2001) “Structure of ribosomal protein TL5 complexed with RNA provides new insights into the CTC family of stress proteins”, Acta Cryst. D 57:968-976
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1999

Selmer, M., Al-Karadaghi, S., Hirokawa, G., Kaji, A. and Liljas, A. (1999) “Crystallization and preliminary X-ray analysis of Thermatoga maritima Ribosome Recycling factor”, Acta Cryst. D 55:2049-2050
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Selmer, M., Al-Karadaghi, S., Hirokawa, G., Kaji, A. and Liljas, A. (1999) “Crystal structure of Thermotoga maritima Ribosome recycling factor: a tRNA mimic”, Science 286:2349-2352
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Last modified: 2022-11-17