Publikationer

Avhandlingar

SANDRA KLEINAU; "Aspects of adjuvants in experimental arthritis and autoimmunity: studies of oil-induced arthritis - a new model of arthritis in rats", 1993.

Förtryck

A three dimensional human immune-tumor cell model reveals the importance of isotypes in antibody-based immunotherapy. Sandra Lara, Jessica C. Anania, Alexander Virtanen, Viktoria Stenhammar & Sandra Kleinau link: https://www.biorxiv.org/content/10.1101/2020.07.01.181800v1

Originalartiklar

57. Lara S, Heilig J, Virtanen A, Kleinau S. Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma. BMC Cancer. 2022 Jun 20;22(1):678.

56. Lara S, Akula S, Fu Z, Olsson AK, Kleinau S, Hellman L. The Human Monocyte-A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation. Int J Mol Sci. 2022 Mar 31;23(7):3890

55. Paivandy A, Akula S, Lara S, Fu Z, Olsson AK, Kleinau S, Pejler G, Hellman L. Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems. Int J Mol Sci. 2022;23(3):1185

54. S. Lara, J.C. Anania, A. Virtanen, V. Stenhammar, Importance of antibody isotypes in antitumor immunity by monocytes and complement using human-immune tumor models. Eur J Immunol. 2021; 51(5):1218-1233.

53. Palm AK, Friedrich HC, Kleinau S. Nodal marginal zone B cells in mice: a novel subset with dormant self-reactivity. Sci Rep. 2016 Jun 9;6:27687. doi: 10.1038/srep27687. PMID:27277419

52. Palm AK, Garcia-Faroldi G, Lundberg M, Pejler G, Kleinau S. Activated mast cells promote differentiation of B cells into effector cells. Sci Rep. 2016 Feb 5;6:20531. doi: 10.1038/srep20531.

51. Matt P, Lindqvist U, Kleinau S. Elevated Membrane and Soluble CD64: A Novel Marker Reflecting Altered FcγR Function and Disease in Early Rheumatoid Arthritis That Can Be Regulated by Anti-Rheumatic Treatment. PLoS One. 2015 Sep 25;10(9):e0137474. doi: 10.1371/journal.pone.0137474.

50. Matt P, Lindqvist U, Kleinau S. Up-regulation of CD64-expressing monocytes with impaired FcγR function reflects disease activity in polyarticular psoriatic arthritis. Scand J Rheumatol. 2015;44(6):464-73. doi: 10.3109/03009742.2015.1020864.

49. Palm AK, Friedrich HC, Mezger A, Salomonsson M, Myers LK, Kleinau S. Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis. Cell Mol Immunol. 2015 Jul;12(4):493-504. doi: 10.1038/cmi.2015.37.

48. Magnusson SE, Wennerberg E, Matt P, Lindqvist U, Kleinau S. Dysregulated Fc receptor function in active rheumatoid arthritis. Immunol Lett. 2014 Nov;162(1 Pt A):200-6. doi: 10.1016/j.imlet.2014.08.016.

47. Olaru F, Wang XP, Luo W, Ge L, Miner JH, Kleinau S, Geiger XJ, Wasiluk A, Heidet L, Kitching AR, Borza DB. Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for α345NC1 hexamers. J Immunol. 2013 Feb 15;190(4):1424-32. doi: 10.4049/jimmunol.1202204.

46. J-E. Park, D. Cullins, L. Zalmundo, S. L. Barnett, A-K. Yi, S. Kleinau, J. M. Stuart, A. H. Kang and L. K. Myers. The molecular basis for the T cell response induced by an altered peptide ligand to type II collagen. The Journal of Biological Chemistry, 2012; 287;19765–174.

45. JJ. Zhang, M. Malekpour, W. Luo, L. Ge, F. Olaru, XP. Wang, Y. Sado, S. Kleinau, A. B. Fogo, DB. Borza. Murine membranous nephropathy induced by immunization with α3(IV) collagen fragment: Subepithelial immune complexes mediate FcγR-independent nephrotic syndrome. Journal of Immunology, 2012; 188:3268-77.

44. K. E. Prokopec, L. Berntson, A. Öman and S. Kleinau. Up regulated complement and Fc receptors in juvenile idiopathic arthritis and correlation with disease phenotype. Journal of Clinical Immunology, 2012; 32:540-50

43. L. K. Myers, D. L. Cullins, D. D. Brand, S. Kleinau, J. M. Stuart, and A. H. Kang. T cells stimulated by an analog peptide of type II collagen require FcRγ to secrete Il-4 and suppress autoimmune arthritis. Arthritis and Rheumatism, 2011;63:2661-70.

42. C. Carnrot, K. E. Prokopec, K. Råsbo, M. C. I. Karlsson and S. Kleinau.Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis. Cellular and Molecular Immunology,2011;8:296-304.

41. K. E. Prokopec, M. Rhodiner, P. Matt, U. Lindqvist, and S. Kleinau. Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis. Clinical Immunology. 2010;137:322-9.

40. K. E. Nilsson, M. Andrén, T. Diaz de Ståhl and S. Kleinau. Enhanced susceptibility to low dose collagen-induced arthritis in CR1/2-deficient female mice – possible role of estrogen on CR1 expression. FASEB J. 2009, 23(8):2450-8.

39. S. E. Magnusson, G. Pejler, S. Kleinau#, and M. Åbrink#. Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis. FASEB J. 2009; 23(3):875-82.#shared last author.

38. S. E. Magnusson, M. Andrén, K. E. Nilsson, P. Sondermann, U. Jacob, and S. Kleinau. Amelioration of collagen-induced arthritis by human recombinant soluble FcgRIIb. Clinical Immunology. 2008; 127(2):225-33.

37. K. Martinsson, L. Carlsson, S. Kleinau, and P. Hultman. The effect of stimulating and inhibiting Fc receptors of murine mercury-induced autoimmunity. Journal of Autoimmunity. 2008; 31(1):22-9.

36. S. E. Magnusson, M. Engström, U. Jacob, A-K. Ulfgren, and S. Kleinau. High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis. Arthritis Research and Therapy. 2007; 9(3):R51.

35. L. Thorvaldson, D. Fuchs, S. E. Magnusson and S. Kleinau. IgG immune complex-binding in macrophages from arthritis-susceptible and arthritis-resistant mice following type II immunization. Scandinavian Journal of Immunology. 2006; 63:347-354.

34. M. Andrén, Z. Xiang, G. Nilsson and S. Kleinau. FcγRIII-expressing macrophages are essential for development of collagen-induced arthritis. Scandinavian Journal of Immunology. 2006; 63:282-289.

33. M. Andrén, B. Johanneson, M. Alarcón-Riquelme and S. Kleinau. IgG Fc receptor polymorphisms and association with autoimmune disease. European Journal of Immunology. 2005; 35:3020-3029.

32. R. Kumar, V. Dammai, P. K. Yadava and S.Kleinau. Gene targeting by ribozyme against TNF-a mRNA inhibits autoimmune arthritis. Gene Therapy. 2005; 12:1486-1493.

31. K.S. Nandakumar, M. Andrén, P. Martinsson, S. Hellström, R. Holmdahl and S. Kleinau. Induction of arthritis by single monoclonal IgG anti-collagen II antibodies and enhancement of arthritis in mice lacking inhibitory FcγRIIB. European Journal of Immunology. 2003; 33:2269-2277.

30. T. Diaz de Ståhl, M. Andrén, P. Martinsson, J. S. Verbeek and S. Kleinau. Expression of FcγRIII is required for development of collagen-induced arthritis. European Journal of Immunology. 2002; 32:2915-2922.

29. M. A. Hietala, I-M. Jonsson, A. Tarkowski, S. Kleinau and M. Pekna. Complement deficiency ameliorates collagen-induced arthritis in mice. Journal of Immunology. 2002; 169:454-459.

28. I. Gjertsson, S. Kleinau and A. Tarkowski. The impact of Fcγ receptors on Staphylococcus aureus infection. Microbial Pathogenesis. 2002; 33:145-152.

27. K.-B Abdul-Majid, A. Stefferl, C. Bourquin, H. Lassmann, C. Linington, T. Olsson, S. Kleinau and R. A. Harris. Fc receptors are critical for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis. Scandinavian Journal of Immunology. 2002; 50:70-81.

26. S. Wernersson, S. Kleinau and B. Heyman. Immune complex-mediated enhancement of antibody responses without induction of delayed-type hypersensitivity. Scandinavian Journal of Immunology. 2000; 52:563-569.

25. S. Kleinau, P. Martinsson and B. Heyman. Induction and suppression of collagen-induced arthritis is dependent on distinct Fc gamma receptors. Journal of Experimental Medicine. 2000; 191:1611-1616.

24. S. Kleinau, P. Martinsson, S. Gustavsson and B. Heyman. Importance of CD23 for collagen-induced arthritis; Delayed onset and reduced severity in CD23-deficient mice. Journal of Immunology. 1999; 162:4266-4270.

23. L. Blomqvist, M . Malm, A. Berg, L. Svelander and S. Kleinau. The inflammatory reaction in elective flap surgery. Plastic and Reconstructive Surgery. 1998; 101:1524-1528.

22. B. Svedrup, L. Klareskog and S. Kleinau. Common commercial cosmetic products induce arthritis in the DA rat. Environmental Health Perspectives. 1998; 106:27-32.

21. H. Erlandsson-Harris, M. Liljeström, E. Lindroos and S. Kleinau. Characterization of adhesion molecule expression in the pathogeneses of homologous collagen-induced arthritis (CIA) in the DA rat. Clinical Immunology and Immunopathology. 1997; 85;40-46.

20. Å. Müssener, J. C. Lorentzen, S. Kleinau and L. Klareskog. Altered Th1/Th2 balance associated with non-major histocompatibility complex genes in collagen-induced arthritis in resistent and non-resistant rat strains. European Journal of Immunoloy. 1997; 27:695-699.

19. L. Svelander, Å. Müssener, H. Erlandsson-Harris and S. Kleinau. Polyclonal Th1 cells transfer oil-induced arthritis. Immunology.1997; 91;260-265.

18. Å. Müssener, K. Funa, S. Kleinau and L. Klareskog. Dynamic expression of transforming growth factor betas (TGF-beta) and their type I and type II receptors in the synovial tissue of arthritic rats. Clinical and Experimental Immunology. 1997; 107:112-119.

17. Å. Müssener, L. Klareskog, J. C. Lorentzen and S. Kleinau. TNF-alpha dominates cytokine mRNA expression in lymphoid tissues of rats developing collagen- and oil-induced arthritis. Scandinavian Journal of Immunology. 1995; 42:128-134.

16. J. C. Lorentzen, H. Erlandsson, Å. Müssener, L. Mattson, S. Kleinau, U. Nyman and L. Klareskog. Specific and long-lasting protection from collagen-induced arthritis and oil-induced arthritis in DA rats by administration of immunogens. Scandinavian Journal of Immunology. 1995; 42:82-89.

15. S. Kleinau, L. Dencker and L. Klareskog. Oil-induced arthritis in DA rats. Tissue distribution of arthritogenic 14C-labelled hexadecane. International Journal of Immunopharmacology. 1995; 17:393-401.

14. S. Kleinau, J. Lorentzen and L. Klareskog. Role of adjuvants in turning autoimmunity into autoimmune disease. Scandinavian Journal of Rheumatology. 1995; 24:179-181.

13. J. Björk, S. Kleinau,T. Mitvedt, L. Klareskog and G. Smedegård. Role of bowel flora for development of immunity to hsp 65 and arthritis in three experimental models. Scandinavian Journal of Immunology. 1994; 40;648-652.

12. I. Lundberg, L. Alfredsson, N. Plato, B. Sverdrup, L. Klareskog and S. Kleinau. Occupation, occupational exposure to chemicals and rheumatological disease. Scandinavian Journal of Rheumatology. 1994; 23:305-310.

11. S. Kleinau, H. Erlandsson and L. Klareskog. Percutaneous exposure of adjuvant oil causes arthritis in DA rats. Clinical and Experimental Immunology. 1994; 96:281-284.

10. S. Kleinau and L. Klareskog. Oil-induced arthritis in DA rats. Passive transfer by T cells but not with serum. Journal of Autoimmunity. 1993; 6:449-458.

9. C. Nordling, S. Kleinau and L. Klareskog. Down-regulation of a spontaneous arthritis in male DBA/1 mice after administration of monoclonal anti-idiotype antibodies to a cross-reactive idiotope on anti-collagen antibodies. Immunology. 1992; 77:144-146.

8. R. Holmdahl, T.J. Goldschmidt, S. Kleinau, C. Kvick and R. Jonsson. Arthritis induced in rats with non-immunogenic adjuvant oil is a genetically restricted, alpha beta T-cell dependent autoimmune disease. Immunology. 1992; 76:197-202.

7. S. Kleinau, H. Erlandsson, R. Holmdahl and L. Klareskog. Adjuvant oils induce arthritis in the DA rat. Journal of Autoimmunity. 1991; 4/6:871-880.

6. S. Kleinau, K. Söderström, R. Kiessling and L. Klareskog. A monoclonal antibody to the mycobacterial 65kDa heat shock protein (ML 30) binds to cells in normal and arthritic joints of rats. Scandinavian Journal of Immunology. 1991; 33:195-202, 1991.

5. P. Larsson, S. Kleinau, J. Mo, R. Holmdahl and L. Klareskog. Homologous collagen II-induced arthritis in rats. Characterization o

f the disease and demonstration of clinically distinct form of arthritis in two strains of rats after immunization with the same collagen preparation. Arthritis and Rheumatism. 1990; 33:693-701.

4. J. Björk and S. Kleinau. Paradoxial effects of LS-2616 (Linomide) treatment in the type II collagen arthritis model in mice. Agents & Actions. 1989; 27:319-321.

3. S. Kleinau, P. Larsson, J. Björk, R. Holmdahl and L. Klareskog. Linomide, a new immunomodulatory drug, show different effects on homologous versus heterologous collagen induced arthritis in rats. Clinical and Experimental Immunology. 1989; 78:138-142.

2. G. Smedegård, J. Björk, S. Kleinau and A. Tengblad. Serum hyaluronate levels reflects disease activity in experimental arthritis models. Agents and Actions. 1989; 27:356-358.

1.J. Björk, S. Kleinau, A. Tengblad and G. Smedegård. Elevated levels of serum hyaluronate and correlation with disease activity in experimental models of arthritis. Arthritis and Rheumatism. 1989; 32:306-311.

Översiktsartiklar

4. Palm AE, Kleinau S. Marginal zone B cells: From housekeeping function to autoimmunity? J Autoimmun. 2021 May;119:102627.

3. S. Kleinau. The impact of Fc receptors on the development of autoimmune diseases. Current Pharmaceutical Design. 2003; 9:1861-1870.

2. L. Klareskog, S.Kleinau, A. Ulfgren, Å, Müssener, H. Erlandsson, J. Lorentzen, J.Rönnelid, A. Eriksson and U. Nyman. Human problems – animal models: Aspects on the use of inducible experimental arthritis for pathogenic studies of human inflammatory joint disease. Rheumatology Highlights 95, Rheumatology in Europe. 1995; 24:8-10.

1.R. Kiessling, A. Grönberg, J. Ivanyi, K. Söderström, M. Ferm, S. Kleinau, E. Nilsson and L. Klareskog. Role of hsp60 during autoimmune and bacterial inflammation. Immunological Reviews. 1991; 121: 91-111.

Bokkapitel

1.T.Hökfelt, R. Mårtensson, A. Björklund, S.Kleinau and M. Goldstein. Distributional maps of tyrosine-hydroxylase-immunoreactive neurons in the rat brain. Handbook of Chemical Neuroanatomy, Vol. 2; 227-379, 1984.

Övriga

1.S. Kleinau. Immunologiska studier av psoriasisartrit. BestPractice, Dermatologi, Sverige, 2010, 2: 4-6 (in Swedish).