The intestine is inhabited by a complex microbial ecosystem containing many hundred bacterial species that coexist peacefully with the host. Occasionally, a pathogenic bacterium invades this ecosystem and distorts gut homeostasis. Gut pathogens are characterized by their ability to interact with/invade host cells of the intestinal mucosa and spark defence mechanisms that may result in intestinal inflammation. In our group, we aim to understand the interplay between invading bacterial pathogens and the epithelial cells of the gut mucosa, during the stepwise progression of intestinal disease.
Read more in our popular science presentation or go directly to our ongoing research.