Department of Cell and Molecular Biology

Publications

2017

Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes. Newton MS, Guo X, Söderholm A, Näsvall J, Lundström P, Andersson DI, Selmer M, Patrick WM. Proc Natl Acad Sci U S A. 2017 May 2;114(18):4727-4732. doi: 10.1073/pnas.1618552114. Epub 2017 Apr 17.

2016

Ieong KW, Uzun Ü, Selmer M, Ehrenberg M. (2016) Two proofreading steps amplify the accuracy of genetic code translation. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13744-13749.

2015

Chen Y, Näsvall J, Wu S, Andersson DI, Selmer M. (2015) Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase. Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2267-77. doi: 10.1107/S1399004715016429.

Söderholm A, Guo X, Newton MS, Evans GB, Näsvall J, Patrick WM, Selmer M. (2015) Two-step Ligand Binding in a (βα)8 Barrel Enzyme: Substrate-bound structures shed new light on thecatalytic cycle of HisA. J Biol Chem. 290(41):24657-68. doi: 10.1074/jbc.M115.678086.

2014

Sun S., Selmer M., Andersson D.I. (2014), “Resistance to β-lactam antibiotics conferred by point mutations in penicillin-binding proteins PBP3, PBP4 and PBP6 in Salmonella enterica.”, PLoS One 9(5):e97202. doi: 10.1371/journal.pone.0097202. eCollection 2014.
Medline  paper 


2013

Punekar A.S. & Selmer M. (2013), “Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli”Acta Cryst. F 69, 1001-1003 First published online: August 19, 2013
Medline  paper 

Punekar A.S., Liljeruhm J., Shepherd T.R., Forster A.C. & Selmer M. (2013), “Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ”, Nucleic Acids Research. doi: 10.1093/nar/gkt719 First published online: August 13, 2013
Medline  paper 

Hultqvist G, Haq SR, Punekar AS, Chi CN, Engström A, Bach A, Strømgaard K, Selmer M, Gianni S, Jemth P. (2013), “Energetic Pathway Sampling in a Protein Interaction Domain.”, Structure doi:pii: S0969-2126(13)00192-5. 10.1016/j.str.2013.05.010. Epub ahead of print
Medline  paper 


2012

Hultqvist G., Punekar A.S., Morrone A., Chi C.N., Engström Å., Selmer M., Gianni S. & Jemth P. (2012), “Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain”, PLOS One. 7(11): 50055. doi:10.1371/journal.pone.0050055
paper 

Punekar A.S., Shepherd T.R., Liljeruhm J., Forster A.C. & Selmer M. (2012), “Crystal structure of RlmM, the 2′O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA”, Nucleic Acids Research. 40(20):10507-20. doi: 10.1093/nar/gks727. Epub 2012 Aug 25.
Medline  paper 

Koripella R.K., Chen Y., Peisker K., Koh C.S., Selmer M. & Sanyal S. (2012), “Mechanism of elongation factor-G mediated fusidic acid resistance and fitness compensation in Staphylococcus aureus”, J. Biol. Chem. 287(36):30257-67.
Medline  pdf 

Selmer M., Gao Y.G., Weixlbaumer A. & Ramakrishnan V. (2012), “Ribosome engineering to promote new crystal forms”, Acta Cryst. D 68:578-583
Medline  paper 

Guo, X., Peisker, K., Bäckbro, K., Chen, Y., Kiran Koripella, R., Mandava, C.S., Sanyal, S. & Selmer, M. (2012), “Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling”, Open Biol., 2: 120016
Medline  paper 


2010

Chen, Y., Kiran Koripella, R., Sanyal, S. and Selmer, M. (2010), “Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid”, FEBS J., 277(18):3789-803
Medline 

Haq S.R., Jürgens M.C., Chi C.N., Koh C.S., Elfström L., Selmer M., Gianni S., Jemth P. (2010), "The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain", J. Biol. Chem., 285(23):18051-9
Medline 


2009

Gao Y.G., Selmer M., Dunham C.M., Weixlbaumer A., Kelley A.C. and Ramakrishnan V. (2009), "The structure of the ribosome with elongation factor G trapped in the posttranslocational state", Science, 326(5953):694-9
Medline 


2008

Selmer, M. and Liljas A. (2008), "Exit biology: battle for the nascent chain."Structure 16:498-500 (preview)
Medline

2007

Dunham, C.M.*, Selmer, M.*, Phelps, S., Kelley, A.C., Suzuki, T., Joseph, S. and Ramakrishnan, V. (2007), “Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S Ribosomal Subunit”, RNA, 13(6):817-23, Epub April 6 2007
*These authors contributed equally
Medline

Weixlbaumer A., Petry, S. #, Dunham, C.M. #, Selmer, M. #, Kelley, A.C. and Ramakrishnan V. (2007), “Crystal structure of the ribosome recycling factor bound to the ribosome”, Nature Struct. Mol. Biol., 14(8): 733-737, Epub July 29 2007; doi:10.1038/nsmb1282
#These authors contributed equally
Medline 


2006

Selmer, M.*, Dunham, C.M.*, Murphy, F.V. IV, Weixlbaumer, A., Petry, S., Kelley, A.C., Weir, J.R. and Ramakrishnan, V. (2006), “Structure of the 70S ribosome complexed with mRNA and tRNA”, Science, Published online September 7 2006; 10.1126/science.1131127
*These authors contributed equally
Medline

2005

Petry, S., Brodersen, D.E., Murphy, F.V. IV, Dunham, C.M., Selmer, M., Tarry, M.J., Kelley, A.C. and Ramakrishnan, V. (2005), “Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon”, Cell 123:1255–1266
Medline

2004

Laurberg, M., Kristensen, O., Selmer, M., Su, X.-D. and Liljas, A. 2004. How do translation factors catalyze protein synthesis. In R. Holland Cheng & Lena Hammar, Eds "Conformational proteomics of Macromolecular Architecture" World Publishing Co. Pte. Ltd. Singapore. Chapter 14, pp307-329.

2003

Nikulin, A., Eliseikina, E., Tishchenko, S., Nevskaya, N., Davydova, N., Platonova, O., Piendl, W., Selmer, M., Liljas, A., Drygin, D., Zimmermann, R., Garber, M. and Nikonov, S. (2003), “Structure of the L1 protuberance in the ribosome”, Nature Struct. Biol. 10(2):104-108
Medline

2002

Selmer, M., Wilting, R., Holmlund, D. and Su, X-D. (2002), “Preparation of a crystallizable mRNA binding domain of Moorella thermoacetica elongation factor SelB”, Acta Cryst D 58:1871-1873
Medline

Selmer, M. and Su, X-D. (2002), “Crystal structure of an mRNA binding fragment of Moorella thermoacetica elongation factor SelB”, EMBO J. 41:4145-4153
Medline

Hirokawa, G., Kiel, M.C., Muto, A., Selmer, M., Liljas, A., Igarashi, K. and Kaji, A. (2002), “Release of tRNA and mRNA from the post-termination complex by Elongation Factor G and Ribosome Recycling Factor, a functional tRNA mimic, EMBO J. 21:2272-2281
Medline

Selmer, M. (2002) “Protein-RNA interplay in translation. Structural studies of RRF, SelB and L1.” doctoral thesis, Lund University
Summary

Kristensen, O., Laurberg, M., Liljas, A. and Selmer, M. (2002), ”Is tRNA mimicry or tRNA binding mandatory for translation factors?” Curr. Prot. Pept. Sci. 3:133-141 (review)
Medline


2001

Fedorov, R., Meshcheryakov,V., Gongadze, G., Fomenkova, N., Nevskaya, N., Selmer, M., Laurberg, M., Kristensen, O., Al Karadaghi, S., Liljas, A., Garber, M. and Nikonov, S. (2001) “Structure of ribosomal protein TL5 complexed with RNA provides new insights into the CTC family of stress proteins” Acta Cryst. D 57:968-976
Medline

1999

Selmer, M., Al-Karadaghi, S., Hirokawa, G., Kaji, A. and Liljas, A. (1999) “Crystallization and preliminary X-ray analysis of Thermatoga maritima Ribosome Recycling factor” Acta Cryst. D 55:2049-2050
Medline Selmer, M., Al-Karadaghi, S., Hirokawa, G., Kaji, A. and Liljas, A. (1999) “Crystal structure of Thermotoga maritima Ribosome recycling factor: a tRNA mimic” Science 286:2349-2352
Medline