Department of Cell and Molecular Biology

Knight lab

Using a powerful combination of X-ray crystallography, molecular biology, and biophysical, biochemical, and computational techniques, we study how proteins and peptides bind to each other to form fibrillar structures such as spider silk, bacterial adhesive fimbriae, or amyloid. Our studies lay the foundation for further work to develop novel applications in medicine (e.g. novel ways for treating bacterial infections or amyloid diseases such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes) and biotechnology (e.g. novel spider silk-based materials).

Read about our ongoing research.