Popular Science Presentation
Enzymes are Nature’s catalysts, reducing the timescale of chemical reactions that would last millions of years to fractions of seconds. No man-made catalyst has ever matched such catalytic proficiency. Thus, it is of great interest to understand how enzymes work and evolve, from both a biochemical and bioengineering perspective. The Kamerlin group uses a range of computational methods to understand how enzyme functionality evolves, and what drives enzyme selectivity in multifunctional enzymes. This is coupled with studies of fundamental chemical reactivity, and methodology development for computational enzymology. In particular, we are interested in understanding the mechanisms and catalysis of phosphoryl transfer reactions: the reactions that drive life, and that are so tremendously difficult to efficiently catalyze. Finally, we have several ongoing side-projects, including studying DNA structure and dynamics, and understanding GTP hydrolysis on the ribosome.