Department of Cell and Molecular Biology



Kositzki, R., Mebs, S., Marx, J., Griese, J. J., Schuth, N., Högbom, M., Schünemann, V., and Haumann, M. (2016) Protonation State of MnFe and FeFe Cofactors in a Ligand-Binding Oxidase Revealed by X-ray Absorption, Emission, and Vibrational Spectroscopy and QM/MM Calculations. Inorg. Chem. 55, 9869-9885.

Kutin, Y., Srinivas, V., Fritz, M., Kositzki, R., Shafaat, H.S., Birrell, J., Bill, E., Haumann, M., Lubitz, W., Högbom, M., Griese, J.J. and Cox, N. (2016) Divergent assembly mechanisms of the manganese/iron cofactors in R2lox and R2c proteins. J. Inorg. Biochem., 162, 164-177.


Griese, J.J., Kositzki, R., Schrapers, P., Branca, R.M.M., Nordström, A., Lehtiö, J., Haumann, M. and Högbom, M. (2015) Structural Basis for Oxygen Activation at a Heterodinuclear Mn/Fe Cofactor. J. Biol. Chem., 290, 25254-25272.

Carter, M., Jemth, A.S., Hagenkort, A., Page, B.D., Gustafsson, R., Griese, J.J., Gad, H., Valerie, N.C., Desroses, M., Boström, J., Warpman Berglund, U., Helleday, T. and Stenmark, P. (2015) Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nat. Commun., 6, 7871. doi: 10.1038/ncomms8871.

Rapatskiy, L., Ames, W., Perez Navarro, M., Savitsky, A., Griese, J.J., Weyhermuller, T., Shafaat, H.S., Högbom, M., Neese, F., Pantazis, D.A. and Cox, N. (2015) Characterization of Oxygen Bridged Manganese Model Complexes using Multifrequency 17O-hyperfine EPR Spectroscopies and Density Functional Theory. J. Phys. Chem. B., 119, 13904-13921.


Shafaat, H.S., Griese, J.J., Pantazis, D.A., Roos, K., Andersson, C.S., Popović-Bijelić, A., Gräslund, A., Siegbahn, P.E.M., Neese, F., Lubitz, W., Högbom, M. and Cox, N. (2014) Electronic structural flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins. J. Am. Chem. Soc., 136, 13399-13409.

Griese, J.J., Srinivas, V. and Högbom, M. (2014) Assembly of nonheme Mn/Fe active sites in heterodinuclear metalloproteins. J. Biol. Inorg. Chem., 19, 759-774.


Griese, J.J., Roos, K., Cox, N., Shafaat, H.S., Branca, R.M.M., Lehtiö, J., Gräslund, A., Lubitz, W., Siegbahn, P.E.M. and Högbom, M. (2013) Direct observation of structurally encoded metal discrimination and ether bond formation in a heterodinuclear metalloprotein. Proc. Natl. Acad. Sci. USA, 110, 17189-17194.

Fenn, S., Schiller, C.B., Griese, J.J., Duerr, H., Imhof-Jung, S., Gassner, C., Moelleken, J., Regula, J.T., Schaefer, W., Thomas, M., Klein, C., Hopfner, K.P. and Kettenberger, H. (2013) Crystal structure of an Anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain. PLoS One 8, e61953.


Griese, J.J. and Högbom, M. (2012) X-ray reduction correlates with soaking accessibility as judged from four non-crystallographically related diiron sites. Metallomics 4, 894-898.

Griese, J.J. and Hopfner, K.P. (2011) Structure and DNA-binding activity of the Pyrococcus furiosus SMC Protein Hinge Domain. Proteins: Struct. Funct. Bioinform., 79, 558-568.

Griese, J.J., Witte, G. and Hopfner, K.P. (2010) Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Nucleic Acids Res., 38, 3454-3465.

Barends, T.R., Hartmann, E., Griese, J.J., Beitlich, T., Kirienko, N.V., Ryjenkov, D.A., Reinstein, J., Shoeman, R.L., Gomelsky, M. and Schlichting, I. (2009) Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase. Nature 459, 1015-1018.

Tyagi, A., Penzkofer, A., Griese, J.J., Schlichting, I., Kirienko, N.V. and Gomelsky, M. (2008) Photodynamics of blue-light-regulated phosphodiesterase BlrP1 protein from Klebsiella pneumoniae and its photoreceptor BLUF domain. Chem. Phys. 354, 130-141. 

Griese, J.J., Jakob, R.P., Schwarzinger, S. and Dobbek, H. (2006) Xenobiotic Reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction. J. Mol. Biol. 361, 140-152.