The goal of our research is to understand the structure and function of physiologically relevant macromolecular complexes. The main biological focus is translation in prokaryotes. Translation is a fundamental process in all living organisms, and increased understanding of this process can be used for development of new or modified antibiotics. We ask detailed questions regarding mechanisms of biogenesis, function and inhibition of the ribosome. We are also interested in other biological processes involving protein-RNA interactions. We use crystallography combined with biochemistry and biophysics as as tools to answer central biological questions regarding how RNA and proteins together generate function.
Read about our ongoing research.