Suparna Sanyal’s group publishes a new ribosome-rescue factor HflX in NSMB


HflX – A ribosome rescue factor for ribosomes stalled under stress

The cells suffer from translational arrest in the adverse conditions, such as heat-shock or other stress.  One major challenge under those conditions is to rescue the stalled ribosomes and to redirect those to new rounds of translation so that synthesis of the proteins essential for handling the stress can be initiated.

Suparna Sanyal’s research group at ICM, in collaboration with Ning Gao’s group in Tsinghua University, Beijing, China have shown that HflX, a conserved GTPase protein, gets induced under heat-shock condition and plays a main role in maintenance of the free ribosome pool by splitting the translationally stalled ribosomes.

The results are published in Nature Structural & Molecular Biology, doi:10.1038/nsmb.3103, (online) 12 October 2015.

Accompanied by high-resolution structure this is the first demonstration of the physiological role of HflX, which can be a drug-target for bacterial diseases.

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