Deindl Lab

Mechanisms of proteins in the regulation of gene expression studied at the single-molecule and atomic level
Our group studies how the structural architectures and dynamics of proteins and protein complexes together enable their function in the regulation of gene expression. One major focus are nucleic-acid interacting enzymes whose aberrant function or dysregulation is often associated with severe disease states such as cancer. In order to understand the function and regulation of these enzymes at a molecular level, we develop and apply single-molecule fluorescence methodologies and combine them with a range of structural approaches, biochemistry and computer simulations.