Department of Cell and Molecular Biology

Selected publications

Berkhoff, B. & Wagner, E.G.H. (2017) RNA-based regulation in type I toxin-antitoxin systems and its implication for bacterial persistence. Curr. Genet. (online May 2017).

Amlinger, L., Hoekzema, M., Wagner, E.G.H., Koskiniemi, S. & Lundgren, M. (2017) Fluorescent CRISPR adaptation reporter for rapid quantification of spacer acquisition. Scientific Reports 7, 10392.

Berkhoff, B., Wagner, E.G.H. & Grabherr, M.G. (2017) RNA-sequence data normalization through in silico prediction of reference genes: the bacterial response to DNA damage as case study. BioData Min. 10.

Berkhoff, B., Hoekzema, M., Aulbach, L. & Wagner, E.G.H. (2017) Two regulatory RNA elements affect TisB-dependent depolarization and persister formation. Mol. Microbiol. 103, 1020-33.

Di Martino, M.L., Romilly, C., Wagner, E.G.H., Colonna, B. & Prosseda, G (2016) One gene and two proteins: a leaderless mRNA supports the translation of a shorter form of  the Shigella VirF regulator. mBio, 7.

Wagner, E.G.H. & Romby, P. (2015) Small Regulatory RNAs in Bacteria: who they are, what they do, and how they do it.  Adv. Genet.  90, 133-208.

Hammann, P, Parmentier, D., Cerciat, M., Reimegård, J., Helfer, A.C., Boisset, S., Guillier, M., Vandenesch, F., Wagner, E.G.H., Romby, P., & Fechter, P. (2014) A method to map changes in bacterial surface composition induced by regulatory RNAs in Escherichia coli and Staphylococcus aureus. Biochimie 106,175-9.

Quax­, T.E.F., Wolf, Y.I., Koehorst, J.J., Wurtzel, O., van der Oost, R., Ran, W., Blombach, F., Makarova, K.S., Brouns, S.J.J., Forster, A.C., Wagner, E.G.H., Sorek, R., Koonin, E.V. & van der Oost, J. (2013) Differential translation tunes uneven production of operon-encoded proteins. Cell Reports 4, 938-944.

Holmqvist, E., Reimegård, J. & Wagner, E.G.H. (2013) Massive functional mapping of a 5'UTR by saturation mutagenesis, phenotypic sorting and deep sequencing. Nucleic Acids Res. 41.

Wagner, E.G.H. (2013) Cycling of RNAs on Hfq. RNA Biol. 10, 591-598.

Wagner, E.G.H. & Unoson, C. (2012) The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes. RNA Biol. 9, 1513-1519.

Holmqvist, E., Unoson, C., Reimegård, J. & Wagner, E.G.H. (2012) A mixed double negative feedback loop between the sRNA MicF and the global regulator Lrp. Mol. Microbiol. 84, 414-427.

Avesson, L., Reimegård, J. Wagner, E.G.H. & Söderbom, F. (2012) MicroRNAs in Amoebozoa: Deep sequencing of the small RNA population in the social amoeba Dictyostelium discoideum reveals developmentally regulated microRNAs. RNA 18, 1771-1782.

Fender, A., Elf, J., Hampel, K., Zimmermann, B., & Wagner, E.G.H. (2010) RNAs actively cycle on Hfq. Genes & Dev. 24, 2621-2626.

Westra, E.R., Pul, Ü, Heidrich, N., Jore, M.M., Lundgren, M., Stratmann, T., Wurm, R., Raine, A., van Heereveld, L., Mastop, M., Wagner, E.G.H., Schnetz, K., van der Oost, J., Wagner, R., Brouns, S.J.J. (2010) H-NS mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO. Mol. Microbiol. 77, 1380-1393.

Holmqvist, E., Reimegård, J., Sterk, M., Grantcharova, N., Römling, U. & Wagner, E.G.H. (2010) Two antisense RNAs target the transcriptional regulator CsgD to inhibit curli synthesis. EMBO J. 29, 1803-1816.

Wagner, E.G.H. (2009) Kill the messenger: bacterial antisense RNA promotes mRNA decay. Nat. Struct. Mol. Biol. 16, 804-806.

Darfeuille, F., Unoson, C., Vogel, J. & Wagner, E.G.H. (2007) An antisense RNA inhibits translation by competing with"standby" ribosomes. Mol. Cell 26, 381-392. [Faculty of 1000: "Must Read"] (on cover)

Udekwu, K., Darfeuille, F., Vogel, J., Reimegård, J., Holmqvist, E. & Wagner, E.G.H. (2005) Hfq-dependent regulation of OmpA synthesis is mediated by an antisense RNA. Genes & Dev. 19, 2355-2366. [Faculty of 1000: "Must Read"]

Vogel, J., Argaman, L., *Wagner, E.G.H., & *Altuvia, S. (2004) The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide. Curr. Biol. 14, 2271-227.

Vogel, J., Bartels, V., Slagter-Jäger, J.G., Hüttenhofer, A. & Wagner, E.G.H. (2003) RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria. Nucleic Acids Res. 31, 6435-6443.

Argaman, L., Hershberg, R., Vogel, J., Bejerano, G., *Wagner, E.G.H., *Margalit, H. & *Altuvia, S. (2001) Novel small RNA-encoding genes in the intergenic regions of Escherichia coli. Curr. Biol. 11, 941-950. *Shared senior authorship. [Faculty of 1000: "Must Read"] (Cover Picture)

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