Department of Cell and Molecular Biology

Selected publications from 2009 onwards

Hanevik K, Kristoffersen E, Mørch K, Rye KP, Sørnes S,Svärd S, Bruserud Ø, Langeland N. (2017). Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome. BMC Immunol. 18(1):5

Ansell BR, Baker L, Emery SJ, McConville MJ, Svärd SG, Gasser RB, Jex AR. (2017). Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines. Front Microbiol. 8:398.

Voleman L, Najdrová V, Ástvaldsson Á, Tůmová P, Einarsson E, Švindrych Z, Hagen GM, Tachezy J, Svärd SG, Doležal P. (2017). Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum. BMC Biol.15(1):27.

Carranza PG, Gargantini PR, Prucca CG, Torri A, Saura A, Svärd S, Lujan HD. (2016). Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia. Int J Biochem Cell Biol. 81(Pt A):32-43.

Xu F, Jerlström-Hultqvist J, Kolisko M, Simpson AG, Roger AJ, Svärd SG, Andersson JO. (2016). On the reversibility of parasitism: adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp.PC1. BMC Biol. 2016 Aug 1;14:62.

Ansell BR, McConville MJ, Baker L, Korhonen PK, Emery SJ, Svärd SG, Gasser RB, Jex AR. (2016). Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis. Antimicrob Agents Chemother. 60(10):6034-45.

Einarsson, E., Ástvaldsson, A., Hultenby,K., Andersson, J.O., Svärd, SG. and Jerlström-Hultqvist, J. (2016). Comparative Cell Biology and Evolution of Annexins in Diplomonads. mSphere.00032-15.

Einarsson E, Troell K, Hoeppner MP, Grabherr M, Ribacke U, Svärd SG. (2016) Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis. PLoS Negl Trop Dis. 10(3):e0004571

Ansell BR, McConville MJ, Baker L, Korhonen PK, Young ND, Hall RS, Rojas CA, Svärd SG, Gasser RB, Jex AR. (2015). Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites. PLoS Negl Trop Dis. 9(12):e0004261.

Saghaug CS, Sørnes S, Peirasmaki D, Svärd S, Langeland N, Hanevik K. (2015). Human Memory CD4+ T Cell Immune Responses against Giardia lamblia. Clin Vaccine Immunol. 23(1):11-8.

Ankarklev J, Franzén O, Peirasmaki D, Jerlström-Hultqvist J, Lebbad M, Andersson J, Andersson B, Svärd SG. (2015). Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates. BMC Genomics. 16(1):697.

Ma'ayeh SY, Knörr L, Svärd SG. (2015). Transcriptional profiling of Giardia intestinalis in response to oxidative stress. Int J Parasitol. 45(14):925-38.

Van Lith L, Šoba B, Vizcaino VV, Svärd S, Sprong H, Tosini F, Pozio E, Cacciò SM. (2015). A real-time assemblage-specific PCR assay for the detection of Giardia duodenalis assemblages A, B and E in fecal samples. Vet Parasitol. 211(1-2):28-34

Einarsson E, Svärd SG, Troell K. (2015). UV irradiation responses in Giardia intestinalis. Exp Parasitol. 154:25-32.

Ferella M, Davids BJ, Cipriano MJ, Birkeland SR, Palm D, Gillin FD, McArthur AG, Svärd S. (2014). Gene expression changes during Giardia-host cell interactions in serum-free medium. Mol Biochem Parasitol. 197(1-2):21-3.

Xu F, Jerlström-Hultqvist J, Einarsson E, Astvaldsson A, Svärd SG, Andersson JO (2014)The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted to Fluctuating Environments. PLoS Genet 10, e1004053.

Stadelmann B, Hanevik K, Andersson MK, Bruserud O, Svärd SG (2013) The role of arginine and arginine-metabolizing enzymes during Giardia - host cell interactions in vitro. BMC Microbiol 13, 256.

Jerlström-Hultqvist J, Einarsson E, Xu F, Hjort K, Ek B, Steinhauf D, Hultenby K, Bergquist J, Andersson JO, Svärd SG (2013) Hydrogenosomes in the diplomonad Spironucleus salmonicida. Nat Commun 4, 2493.

Franzen O, Jerlström-Hultqvist J, Einarsson E, Ankarklev J, Ferella M, Andersson B, Svärd SG (2013) Transcriptome profiling of Giardia intestinalis using strand-specific RNA-seq. PLoS Comput Biol 9, e1003000.

Vanni I, Caccio SM, van Lith L, Lebbad M, Svärd SG, Pozio E, Tosini F (2012) Detection of Giardia duodenalis assemblages A and B in human feces by simple, assemblage-specific pcr assays. PLoS Negl Trop Dis 6, e1776.

Stadelmann B, Merino MC, Persson L, Svärd SG (2012) Arginine consumption by the intestinal parasite Giardia intestinalis reduces proliferation of intestinal epithelial cells. PLoS One 7, e45325.

Jerlström-Hultqvist J, Stadelmann B, Birkestedt S, Hellman U, Svärd SG (2012) Plasmid vectors for proteomic analyses in Giardia: Purification of virulence factors and analysis of the proteasome. Eukaryot Cell 11, 864-873.

Jerlström-Hultqvist J, Einarsson E, Svärd SG (2012) Stable transfection of the diplomonad parasite Spironucleus salmonicida. Eukaryot Cell 11, 1353-1361.

Ankarklev J, Svärd SG, Lebbad M (2012) Allelic sequence heterozygosity in single Giardia parasites. BMC Microbiol 12, 65.

Ankarklev J, Hestvik E, Lebbad M, Lindh J, Kaddu-Mulindwa DH, Andersson JO, Tylleskar T, Tumwine JK, Svärd SG (2012) Common coinfections of Giardia intestinalis and Helicobacter pylori in non-symptomatic ugandan children. PLoS Negl Trop Dis 6, e1780.

Skarin H, Ringqvist E, Hellman U, Svärd SG (2011) Elongation factor 1-alpha is released into the culture medium during growth of Giardia intestinalis trophozoites. Exp Parasitol 127, 804-810.

Ringqvist E, Avesson L, Soderbom F, Svärd SG (2011) Transcriptional changes in Giardia during host-parasite interactions. Int J Parasitol 41, 277-285.

Lebbad M, Petersson I, Karlsson L, Botero-Kleiven S, Andersson JO, Svenungsson B, Svärd SG (2011) Multilocus genotyping of human Giardia isolates suggests limited zoonotic transmission and association between assemblage B and flatulence in children. PLoS Negl Trop Dis 5, e1262.

Jenikova G, Hruz P, Andersson MK, Tejman-Yarden N, Ferreira PC, Andersen YS, Davids BJ, Gillin FD, Svärd SG, Curtiss R, 3rd, Eckmann L (2011) Alpha1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model. Vaccine 29, 9529-9537.

Roxstrom-Lindquist K, Jerlström-Hultqvist J, Jorgensen A, Troell K, Svärd SG, Andersson JO (2010) Large genomic differences between the morphologically indistinguishable diplomonads Spironucleus barkhanus and Spironucleus salmonicida. BMC Genomics 11, 258.

Lebbad M, Mattsson JG, Christensson B, Ljungstrom B, Backhans A, Andersson JO, Svärd SG (2010) From mouse to moose: Multilocus genotyping of Giardia isolates from various animal species. Vet Parasitol 168, 231-239.

Jerlström-Hultqvist J, Franzen O, Ankarklev J, Xu F, Nohynkova E, Andersson JO, Svärd SG, Andersson B (2010) Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate. BMC Genomics 11, 543.

Jerlström-Hultqvist J, Ankarklev J, Svärd SG (2010) Is human giardiasis caused by two different Giardia species? Gut Microbes 1, 379-382.

Hofstetrova K, Uzlikova M, Tumova P, Troell K, Svärd SG, Nohynkova E (2010) Giardia intestinalis: Aphidicolin influence on the trophozoite cell cycle. Exp Parasitol 124, 159-166.

Birkeland SR, Preheim SP, Davids BJ, Cipriano MJ, Palm D, Reiner DS, Svärd SG, Gillin FD, McArthur AG (2010) Transcriptome analyses of the Giardia lamblia life cycle. Mol Biochem Parasitol 174, 62-65.

Ankarklev J, Jerlström-Hultqvist J, Ringqvist E, Troell K, Svärd SG (2010) Behind the smile: Cell biology and disease mechanisms of Giardia species. Nat Rev Microbiol 8, 413-422.

Pathuri P, Nguyen ET, Ozorowski G, Svärd SG, Luecke H (2009) Apo and calcium-bound crystal structures of cytoskeletal protein alpha-14 giardin (annexin E1) from the intestinal protozoan parasite Giardia lamblia. J Mol Biol 385, 1098-1112.

Franzen O, Jerlström-Hultqvist J, Castro E, Sherwood E, Ankarklev J, Reiner DS, Palm D, Andersson JO, Andersson B, Svärd SG (2009) Draft genome sequencing of Giardia intestinalis assemblage B isolate GS: Is human giardiasis caused by two different species? PLoS Pathog 5, e1000560.

Click here for a complete PubMed list of publications.