Department of Cell and Molecular Biology

Publications

2017

119. Fu Z, Thorpe M, Alemayehu R, Roy A, Kervinen J, de Garavilla L, Åbrink M, Hellman L. Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G. J Immunol. 2017 Feb 15;198(4):1474-1483. doi: 10.4049/jimmunol.1601223.

2016

118. Thorpe M, Akula S, Hellman L. Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells. Dev Comp Immunol. 2016 Oct;63:84-95. doi: 10.1016/j.dci.2016.05.013.

117. Fu Z, Thorpe M, Akula S, Hellman L. Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution. PLoS One. 2016 May 6;11(5):e0154886. doi: 10.1371/journal.pone.0154886.

2015

116. Akula S, Thorpe M, Boinapally V, Hellman L. Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution. PLoS One. 2015 Dec 22;10(12):e0145592. doi: 10.1371/journal.pone.0145592.

115. Fu Z, Thorpe M, Hellman L.  rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins. PLoS One. 2015 Jun 26;10(6):e0131720. doi: 10.1371/journal.pone.0131720.

114. Chahal G, Thorpe M, Hellman L. The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin. PLoS One. 2015 Jun 25;10(6):e0129511. doi: 10.1371/journal.pone.0129511.

113. Saupe F, Huijbers EJ, Hein T, Femel J, Cedervall J, Olsson AK, Hellman L. Vaccines targeting self-antigens: mechanisms and efficacy-determining parameters. FASEB J. 2015 Aug;29(8):3253-62. doi: 10.1096/fj.15-271502.

2014

112. Akula S, Mohammadamin S, Hellman L. Fc receptors for immunoglobulins and their appearance during vertebrate evolution. PLoS One. 2014 May 9;9(5):e96903. doi: 10.1371/journal.pone.0096903. Erratum in: PLoS One. 2015;10(4):e0124530.

2013

111. Ahooghalandari P, Hanke N, Thorpe M, Witte A, Messinger J, Hellman L. Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors. PLoS One. 2013 Jun 19;8(6):e65988. doi: 10.1371/journal.pone.0065988.

2012

110. Grundström J, Reimer JM, Magnusson SE, Nilsson G, Wernersson S, Hellman L. Human cord blood derived immature basophils show dual characteristics, expressing both basophil and eosinophil associated proteins. PLoS One. 2012;7(10):e48308. doi: 10.1371/journal.pone.0048308.

109. Thorpe M, Yu J, Boinapally V, Ahooghalandari P, Kervinen J, Garavilla Ld, Hellman L. Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase. Int Immunol. 2012 Dec;24(12):771-82. doi: 10.1093/intimm/dxs081.

108. Gallwitz M., Enoksson, M., Thorpe, M. and Hellman, L.
The extended substrate specificity of human thrombin.
PLoS One. 7 (2012) :e31756. Epub 2012 Feb 27.

107. Huijbers EJM., Femel J., Andersson K., Björkelund H., Hellman L. and Olsson AK. The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund’s in a cancer vaccine targeting ED-B - a prerequisite for clinical development. Vaccine 30 (2012) 225-230. Epub 2011 Nov 10.

2011

106. Korkmaz B., Jégot G., Lau LC., Thorpe M., Pitois E., Juliano L., Walls AF., Hellman L. and Gauthier F. Discriminating between the activities of human cathepsin G and chymase using intramolecularly quenched fluorogenic substrates. FEBS Journal 278 (2011):2635-46.

2010

105. Nandakumar KS., Jansson A., Xu B, Rydell N., Ahooghalandari P., Hellman L., Blom AM., Holmdahl R. A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. PLoS One. 20 (2010) e13511.

104. Huijbers E. JM, Ringvall M., Femel J., Kalamajski S., Lukinius, Abrink M., Hellman L. and Olsson A-K. Vaccination against the extra domain-B of fibronectin as a novel tumor therapy. FASEB J. 24 (2010) 4535-4544.

103. Andersson M. K., Thorpe, M. and Hellman, L. Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in the P2´position of substrates. FEBS J. 277 (2010) 2255-2267.

102. Reimer J. M. Samollow, P.B. and Hellman, L. High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution. Immunogenetics 62 (2010) 369-382.

101. Gallwitz M., Enoksson, M. Thorpe, M., Ge, X. and Hellman, L. The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase.
Int. Immunol. 22 (2010) 421-431.

100. Vernersson, M., Belov, K., Aveskogh, M., and Hellman, L.
Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed Platypus, Ornithorhynchus anatinus.
Mol. Immunol. 47 (2010) 785-791.

2009

99. Ringvall M., Huijbers E., Ahooghalandari, P., Alekseeva, L., Andronova, T., Olsson A-K. and Hellman L. Identification of potent biodegradable adjuvants that efficiently break self-tolerance - A key issue in therapeutic vaccine development. Vaccine 28 (2009) 48-52.

98. Zhao Y., Cui H., Whittington C., Wei Z., Zhang X., Zhang Z., Ren L., Hu, X., Zhang, Y., Hellman L., Pan-Hammarström Q., Belov K., Li N., and Hammarström L. Ornithorhynchus anatinus (platypus) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods.
J. Immunol. 183, (2009), 3285-3293.

97. Charles, N., Watford, W.T., Ramos, H.L., Hellman, L. Oettgen, H.C., Gomez, G., Ryan J.J. O’Shea, J.J., and Rivera, J. Homeostatic control of basophil GATA-3 expression and TH2 differentiation by Lyn kinase.
Immunity 2009 Apr;30(4):533-543.

96. Andersson, MK., Enoksson, M. Gallwitz, M. and Hellman, L.
The extended substrate specificity of the human mast cell chymase reveals a serine protease with a well-defined substrate recognition profile.
Int. Immunol 2009 Jan;21(1):95-104. Epub 2008 Dec 10.

2008

95. Andersson, M., Pemberton, AD., Karlson, U., Miller, HR and Hellman, L.
Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse - high specificity indicates high substrate selectivity.
Molecular Immunology 45 (2008) 1976-80.

94. Ledin, A., Arnemo, J., Liberg, O. and Hellman, L.
High plasma IgE levels in the Scandinavian wolf population, and its implications for mammalian IgE homeostasis.
Molecular Immunology 45 (2008) 1976-1980.

93. Hellman, L. Therapeutic vaccines against IgE mediated allergies.
Expert Review of Vaccines 7 (2008) 193-208.

92. Reimer, J., Enoksson , M., Samollow P.B. and Hellman, L.
The extended substrate specificity of opossum chymase –implications for the origin of mast cell chymases. Molecular Immunology 45 (2008) 2116-2125.

91. Andersson, MK., Karlson, U. and Hellman, L.
The extended cleavage specificity of the rodent hchymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase Molecular Immunology 45 (2008) 766-775.

2007

90. Gallwitz M., Enoksson, M. and Hellman, L. Expression profile of novel members of the rat mast cell protease (rMCP)-2 and -8 families, and functional analysis of mouse mast cell protease (mMCP) -8.
Immunogenetics 59 (2007) 391-405.

89. Henningsson, F., Åbrink, M., Hellman, L., and Pejler G. Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. Biochem. J 403 (2007) 49-57.

88. Johansson, J., and Hellman, L. Modifications increasing the efficacy of recombinant vaccines: marked increase in antibody titers with moderately repetitive variants of a therapeutic allergy vaccine.
Vaccine 25 (2007) 1676-1682.

87. Hellman, L. Regulation of IgE homeostasis, and the identification of potential targets for therapeutic intervention.
Biomedicine & Pharmacotherapy 61 (2007) 34-49.

2006

86. Gallwitz, M. Reimer, J. and Hellman, L.
Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution. Immunogenetics 58 (2006) 655-669.

85. Reimer, J., Gallwitz, M., Juremalm, M., Nilsson, G. and Hellman, L. and Wernersson, S. . Isolation of transcriptionally active umbilical cord blood-derived basophils expressing Fcso, HLA-DR and CD 203c.
Allergy 61 (2006) 1063-1070.

84. Gallwitz, M. and Hellman, L.
Rapid species-specific diversification of the mast cell chymase locus during mammalian evolution. Immunogenetics 58 (2006) 641-654.

83. Wernersson, S., Reimer, J., Poorafshar, M., Karlsson, U.,Wermenstam, N., Bengtén, E., Wilson, M., Pilström, L. and Hellman, L.
Granzyme-like sequences in bony fish shed light on the emergence of hematopoietic serine proteases during vertebrate evolution.
Dev. Comp. Immunol. 30 (2006) 901-918.

82. Parra ZE, Arnold T, Nowak MA, Hellman L, Miller RD. TCR gamma chain diversity in the spleen of the duckbill platypus (Ornithorhynchus anatinus).
Dev. Comp. Immunol. 30 (2006) 699-710.

81. Ledin, A. Bergvall, K., Salmon Hillbertz, N., Hansson, H., Andersson, G., Hedhammar, Å. and Hellman, L. Generation of therapeutic antibody responses against IgE in dogs, an animal species with exceptionally high plasma IgE levels. Vaccine 24 (2006) 66-74.

2005

80. Johansson, J., Salazar, J., Aveskogh, M., Munday, B,. Miller R. and
Hellman, L. High variability in complementarity-determining regions compensate for a low number of V-gene families in the  High variability in complementarity-determiImmunol. 35 (2005); 3008-3019.

79. Feyerabend, TB., Hausser, H., Tietz, A., Blum, C., Hellman, L., Strauss, AH., Takahashi, HK., Morgan, ES., Dvorak, AM., Fehling, HJ. and Rodewald, H.-R. Loss of histochemical identity in mast cells lacking carboxypeptidase A. Mol.Cell Biol. 25 (2005); 6199-6210.

2004

78. Nowak, MA., Parra, ZE.,Hellman, L. and Miller RD.
The complexity of expressed kappa light chains in egg-laying mammals. Immunogenetics 56 (2004); 555-563.

77. Belov, K., Miller, RD., Ilijeski, A., Hellman, L. and Harrison,GA. Isolation of monotreme T cell receptor a and b chains.
Immunogenetics 56 (2004); 164-169.

76. Johansson, J., Ledin, A., Vernersson, M., Lövgren-Bengtsson K.and Hellman, L. Identification of adjuvants that enhance the therapeutic antibody response to host IgE. Vaccine 22 (2004); 2873-2880.

75. Looman, C., Hellman, L. and Åbrink, M.,
A novel Krüppel associated box identified in a panel of mammalian zinc finger proteins. Mammalian Genome 15 (2004); 35-40.

74. Vernersson, M., Aveskogh, M. and Hellman L. Characterization of IgE from a monotreme the Australian Echidna (Tachyglossus aculeatus) and a comparative analysis of  and a comparative analysis of monotreme the Aust
Dev Comp Immunol. 28 (2004); 61-75.


2003

73. Looman, C., Åbrink, M., Mark, C and Hellman, L
MZF6D, a novel KRAB zinc finger gene expressed exclusively in meiotic male germ cells. DNA Cell Biol. 22 (2003);489-96.

72. Belov, K., Lam, MKP., Hellman L. and Colgan, DJ.
Evolution of the major histocompatibility complex: Isolation of class II vcDNAs from two monotremes, the platypus and the short-beaked echidna
Immunogenetics 55 (2003); 402-411.

71. Karlson, U., Pejler, G., Fröman, G, and Hellman, L.
Extended substrate specificity of rat mast cell protease 5, a rodent a chymase with elastase like primary specificity. J Biol Chem. 278 (2003); 39625-39631.

70. Belov K. and Hellman L. Immunoglobulin genetics of Ornithorhynchus anatinus (platypus) and Tachyglossus aculeatus (short-beaked echidna). Comp Biochem Physiol A Mol Integr Physiol.136 (2003); 811-819.

69. Belov K. and Hellman L. Platypus IgM and the divergence of the two extant monotreme lineages. Australian Mammology 25 (2003); 87-94.

68. Miska, K.B., Hellman, L. and Miller R.D. Characterization of  and Miller R.D. Characterization of wo extant monotreme lineages.6 (2003); 811-819.stasethe short-beaked echidna, and the grey short-tailed opossum.
Dev. Comp. Immunol. 3 (2003);247-256.

2002

67. Miska, K.B., Harrison, G.A., Hellman, L. and Miller R.D. The major histocompatibility complex in monotremes: An analysis of the evolution of the MHC class I genes across all three mammalian subclasses. Immunogenetics 54 (2002); 381-393.

66. Looman, C., Åbrink, M., Mark, C. and Hellman, L.. KRAB zinc finger proteins; an analysis of the molecular mechanisms governing their increase in numbers and complexity during evolution.
Mol. Biol. Evol. 12 (2002);2118-30.

65. Vernersson, M., Aveskogh, M., Munday, B. and Hellman, L. Evidence for an early appearance of modern post switch immunoglobulin isotypes in mammalian evolution (II), cloning of IgE, IgG1 and IgG2 from a monotreme, the duckbilled platypus Ornithorhynchus anatinus.
Eur.J. Immunol. 32 (2002); 2145-2155.

64. Johansson, J., Aveskogh, M., Munday, B., and Hellman, L. Heavy chain V-region diversity in the duck-billed platypus (Ornithorhynchus anatinus); long and highly variable complementary-determining region 3 compensates for limited germline diversity. J Immunol.168 (2002); 5155-5162

63. Karlson, U., Pejler, G., Fröman, G, and Hellman, L.
Rat mast cell protease 4, a achymase with a unusually stringent substrate specificity. J. Biol. Chem. 277 (2002); 18579-18585.

62. Henningsson, F., Ledin, J., Lunderius, C., Hellman, L. and Pejler, G.
Altered storage of proteases in mast cells from mice lacking heparin. A possible role for heparin in carboxypeptidase A processing.
Biol. Chem. 383 (2002); 793-801.

61. Belov, K., Hellman, L. and Cooper, D.W. Characterization of echidna IgM provides insight into the time of divergence of extant mammals.
Dev Comp. Immunol. 26 (2002); 831-839.

60. Belov, K., Zenger, K.R., Hellman, L. and Cooper, D.W. Echidna IgA supports mammalian unity and traditional Therian relationship.
Mammalian Genome 13 (2002); 656-663.

59. Belov, K., Hellman, L. and Cooper, D.W. Characterization of IgG from a monotreme, Tachyglossus aculeatus. Immunogenetics 53 (2002);1065-1071.

58. Vernersson, M., Kempe, A., Johansson, J. and Hellman, L. Generation of therapeutic antibody responses against IgE through vaccination.
The FASEB Journal 16 (2002) 875-877 + On Line.

2001

57. Ohtsu H, Tanaka S, Terui T, Hori Y, Makabe-Kobayashi Y, Pejler G, Tchougounova E, Hellman L, Gertsenstein M, Hirasawa N, Sakurai E, Buzas E, Kovacs P, Csaba G, Kittel A, Okada M, Hara M, Mar L, Numayama-Tsuruta K, Ishigaki-Suzuki S, Ohuchi K, Ichikawa A, Falus A, Watanabe T, Nagy A.
Mice lacking histidine decarboxylase exhibit abnormal mast cells.
FEBS Lett. 502 (2001): 53-56.

56. Mark, C., Looman, C., Åbrink, M. and Hellman, L.
Molecular cloning and a preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19.
DNA and Cell Biology 20 (2001) 275-286.

55. Lunderius, C. and Hellman, L. Characterization of the gene for mouse mast cell protease 8, and a comparative analysis of hematopoietic serine protease genes. Immunogenetics 53 (2001) 225-232.

54. Åbrink, M., Ortiz, J.A., Mark, C., Sanches, C., Looman, C., Hellman, L., Chambon, P. & Losson, R. Conserved interaction between distinct KRAB domains and the transcriptional corepressor TIF1o
Proc. Natl. Acad. Sci. USA 98 (2001) 1422-1426.

2000

53. Poorafshar, M., Aveskogh, M., Munday, B. and Hellman, L.
Identification and structural analysis of four serine proteases in a monotreme, the platypus, Ornithorhynchus anatinus. Immunogenetics 52 (2000) 19-28.

52. Lunderius, C., Xiang, Z., Nilsson, G. & Hellman, L.
Murine mast cell lines as indicators of early events in mast cell and basophil development. Eur. J. Immunol. 30 (2000) 3396-3402.

51. Hallgren, J., Karlsson, U., Poorafshar, M., Hellman, L. and Pejler, G. Mechanism for activation of mouse mast cell tryptase. Dependence on heparin and acidic pH for formation of active tetramers of mouse mast cell protease 6. Biochemistry 39 (2000) 13068-13077.

50. Poorafshar, M., Helmby, H., Troye-Blomberg, M., & Hellman, L.
MMCP-8, the first lineage specific differentiation marker for mouse basophils; Elevated numbers of potent IL-4 producing and MMCP-8 positive cells in spleens of malaria infected mice.
Eur J. Immunol. 30 (2000) 2660-2668.

49. Åbrink, M., Larsson, E., Gobl, A. and Hellman, L. Expression of lactoferrin in the kidney; implications for innate immunity and iron metabolism.
Kidney International 57 (2000) 2004-2010.

1999

48. Aveskogh, M. Pilström, L. and Hellman, L. Cloning and structural analysis of IgM (achain) and an analysis of the immunoglobulin heavy chain V gene repertoire in the marsupial Monodelphis domestica.
Dev. Comp. Immunol. 23 (1999) 597-606.

47. Forsberg, E., Pejler, G., Ringvall, M., Lunderius, C. Tomasini-Johansson, B., Kusche-Gullberg, M., Hellman, L. and Kjellén, L. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Nature 400 (1999) 773-776.

46. Mark, C., Åbrink, M. and Hellman, L. A comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionary distinct subfamilies of KRAB zinc finger genes.
DNA and Cell Biol. 18 (1999) 381-396.

45. Poorafshar, M. and Hellman, L. Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis.
Eur. J. Biochem. 161 (1999) 244-250.

1998

44. Hellman, L. Vaccines Against Allergies (Chapter 19). In Handbook of Experimental Pharmacology, Volume 133 ¨Vaccines¨, (1998) pages 499-526. Eds P. Perlmann and H. Wigzell. Springer- Verlag GmbH & Co.KG Heidelberg.

43. Lützelschwab, C., Lunderius, C., Enerbäck, L. and Hellman, L.; A kinetic analysis of the expression of mast cell protease mRNA in the intestines of Nippostrongylus brasiliensis infected rats.
Eur J. Immunol. 28 (1998) 3730-3737.

42. Aveskogh, M. and Hellman, L. Evidence for an early appearance of modern post switch isotypes in mammalian evolution; Cloning of IgE, IgG and IgA from the marsupial Monodelphis domestica.
Eur. J. Immunol. 28 (1998) 2738-2750.

41. Andersson, E., Hellman, L., Gullberg, U. and Olsson, I. The role of the propeptide for processing and sorting of human myeloperoxidase.
J. Biol. Chem. 273 (1998) 4747-4753.

40. Lützelschwab, C., Huang, R., Aveskogh, M. and Hellman, L. Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur J. Immunol. 28 (1998) 1022-1033.

39. Åbrink, M., Larsson, E., and Hellman, L. Demethylation of ERV3, an endogenous retrovirus regulating the krüppel related zinc finger gene H-plk, in several human cell lines arrested during early monocyte development. DNA and Cell Biol. 17 (1998) 27-37.


1997

38. Vernersson, M., Pejler, G. Kristersson, T., Alving K. and Hellman, L. Cloning, structural analysis and expression of the -chain of pig IgE.
Immunogenetics 46 (1997) 461-468.

37. Aveskogh, M., Lützelschwab, C., Huang, M. and Hellman, L. ; Characterization of cDNA clones encoding mouse proteinase 3 (myeloblastine) and cathepsin G. Immunogenetics 46 (1997), 181-191.

36. Lützelschwab, C., Pejler, G., Aveskogh, M. and Hellman, L. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations.
J. Exp. Med.185 (1997) 13-29.

1996

35. Blom, T., Nilsson, G., Sundström, C. Nilsson, K. and Hellman, L. Characterization of a human basophil like cell line (LAMA-84).
Scand. J. Immunol 44 (1996) 54-61.

34. Nilsson, G., Blom, T., Sundström, C., Nilsson, K. and Hellman, L.
Stem cell factor-dependent human cord blood derived mast cells express tand  tryptase, heparin and chondroitin sulphate.
Immunology 88 (1996) 308-314.

33. Hellman, L. and Carlsson, M. Allergy Vaccines: A Review of Developments. A Review article prepared upon invitation for the
Journal for Clinical Immunotherapeutics 6 (1996) 130-142.

32. Hellman, L. Is vaccination against IgE possible?
Adv Exp Med Biol 409 (1996) 337-342.

1995

31. Aveskogh, M. Hellman, L. A single major transcript encodes the membrane bound form of rat immunoglobulin E. Scand. J. Immunol.42 (1995) 535-539.

30. Åbrink, M., Aveskogh, M. and Hellman, L. Isolation of cDNA clones for 42 different Krüppel related zinc finger proteins expressed in the human monoblast cell line U-937. DNA and Cell Biology, 14 (1995) 125-136.

1994

29. Huang, R. and Hellman L. Genes for mast cell serine protease(s) and their molecular evolution. Immunogenetics 40 (1994) 397-415.

28. Åbrink, M., Gobl, A., Huang, R., Nilsson, K. and Hellman, L. Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte macrophage cell lineage. Leukemia 8 (1994) 1579-1584.

27. Nilsson G., Blom, T. Sundström K., Butterfield R., Nilsson K. and
Hellman, L. Phenotypic characterization of the human mast cell line HMC-1.
Scand. J. Immunol. 39 (1994) 489-498.

26. Hellman, L. Profound reduction in allergen sensitivity following treatment with a novel allergy vaccine. Eur. J. Immunol. 24 (1994) 415-420.

1993

25. Huang, R., Åbrink, M., Aveskogh, M., Gobl, A., Larsson, L.-G., Nilsson, G., Nilsson, K. and Hellman, L. Expression of a mast cell tryptase in the human monocytic cell lines U-937 and Mono Mac 6.
Scand. J. Immunol. 38, (1993) 359-367,

24. Blom, T. and Hellman, L. Characterization of a tryptase mRNA expressed in the human basophil cell line KU812. Scand. J. Immunol. 37, (1993) 203-208,

23. Hellman, L. Characterization of four novel  chain mRNA and a comparative analysis of genes for immunoglobulin E in rodents and man.
Eur. J. Immunol. 23, (1993) 159-167,

22. Forsberg, K., Nilsson G. Ren, Z.P., Hellman, L., Westermark, B. and Nister, M. Constitutive and inducible expression of PDGF in the human basophilic cell line, KU812. Growth factors 9 (1993) 231-241.

1992

21. Blom, T., Huang, R., Nilsson, K. and Hellman, L. Phenotypic characterization of KU812; a cell line identified as an immature human basophilic leucocyte. Eur. J. Immunol. 22 (1992) 2025-2032.

1991

20. Nilsson, G., Jernberg, H., Hellman, L., Ahlstedt, S. and Nilsson, K.
Enhancement of IgE synthesis in the human myeloma cell line U-266 with an IgE binding factor purified from a human T-cell line.
Scand. J. Immunol. 34 (1991) 721-726.

19. Huang, R., Blom, T. and Hellman, L. Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell specific serine proteases. Eur. J. Immunol. 21 (1991) 1611-1621.

1990

18. Angerth, T., Huang, R., Aveskogh, M., Pettersson,I., Kjellen, L. and Hellman,L. Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein; analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome.
Gene 93 (1990) 253- 256.

1989

17. Kjellen L.,Pettersson I., Lillhager P., Steen M.-L., Pettersson U., Lehtonen P.,Karlsson T., Rouslahti E. and Hellman L. Primary structure of a mouse mast cell tumor proteoglycan core protein.
Biochemical J. 263 (1989) 105-113.

16. Hellman L., Smedsröd B., Sandberg H. and Pettersson U. Secretion of coagulant factor VIII activity and antigen by rat liver sinusoidal endothelial cells. British Journal of Haematology 73 (1989) 248-355.

1988

15. Nelsen B., Hellman L. and Sen R. The NFB binding site mediates phorbol ester-inducible transcription in non-lymphoid cells.
Mol. Cell. Biol. 8 (1988) 3526-3531.

14. Hellman L., Steen M.-L., Sundvall M. and Pettersson U. A rapidly evolving region in the immunoglobulin heavy chain loci of rat and mouse; postulated role of (dC-dA)n-(dG-dT)n sequences. Gene 68 (1988) 93-100.

13. Hellman L., Josephson S., Jernberg H., Nilsson K. and Pettersson U.
Immunoglobulin synthesis in the human myeloma cell line U-266; expression of two heavy chain isotypes (and ) after long term cultivation in vitro.
Eur. J. Immunol.18 (1988) 905-910.

1987

12. Steen M.-L., Hellman L.and Pettersson U. The immunoglobulin lambda locus in rat consists of two C genes and a single V gene. Gene 55 (1987) 75-84.

11. Hellman L. and Pettersson U. Analysis of closely related genes by the use of synthetic oligonucleotide probes labeled to a high specific activity.
Gene Anal.Techn. 4.(1987) 9-13.

10. Forsbäck C., Hellman L., Danersund A., Tötterman T., Pettersson U. and Nilsson K. TPA-induced differentiation of chronic leukemia cells: studies of µ chain expression. Leukemia 1 (1987) 38-43.

1986

9. Nilsson K., Larsson L.-G., Carlsson M., Danersund A., Forsbäck C., Hellman L., Tötterman T. and Pettersson U. Expression of c-myc and c-fos during phorbol ester induced differentiation of B-type chronic leucemia cells.
In: Potters M. and Melchers F.: Mechanisms of B-cell neoplasia.

1985

8. Nilsson K., Tötterman T., Danersund A., Forsbäck K., Hellman L. and Pettersson U. Phorbol ester (TPA) induced differentiation of B-type chronic lymphocytic leucemia cells. In Molecular Biology of Tumor Cells. edited by B.Wahren et al. Raven Press, New York (1985) 233-242.

7. Hellman L. Genes for immunoglobulin E: structure, rearrangement and expression. Thesis. Acta Univ.Uppsaliensis No 797, (1985) ISBN 91-554-1721-3.

6. Hellman L., Steen M.-L. and Pettersson U. Nonfunctional immunoglobulin light chain transcripts in two IgE producing rat immunocytomas: implications for allelic exclusion and transcription activation processes. Gene 40 (1985) 115-124.

5. Hellman L., Engström Å., Bennich H. and Pettersson U. Structure and expression of -chain genes in two IgE producing rat immunocytomas. Gene 40 (1985) 107-114.

1984

4. Steen M.-L., Hellman L. and Pettersson U. The rat immunoglobulin E heavy chain locus. J. Mol. Biol.177 (1984) 19-32.

1983

3. Bywater M., Bywater R. and Hellman L. A novel chromatographic procedure for purification of bacterial plasmids.
Analytical Biochemistry 132 (1983) 219-224.

1982

2. Hellman L., Pettersson U., Engström Å., Karlsson T. and Bennich H.
Structure and evolution of the heavy chain from rat immunoglobulin E.
Nucl. Acids Res. 10 (1982) 6041-6049.

1. Hellman L., Pettersson U. and Bennich H. Characterization and molecular cloning of the mRNA for the heavy ( ) chain of rat immunoglobulin E.
Proc. Natl. Acad. Sci. USA 79 (1982) 1264-1268.